MRC Clinical Trials Unit at UCL
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What is a randomised clinical trial?
What is an observational study?
How do we make sure a trial is safe?
How is a trial designed and run?
What happens at the end of a trial?
Taking Part in a Clinical Trial
How can you take part in a trial?
What questions should you ask before participating in a trial?
Patient and Public Involvement
About our PPI group
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Improving the clinical trials ecosystem
NIHR Associate Principal Investigator (PI) Scheme
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Posters
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Use of participate in OCTOPUS
Exploring different objectives in non-inferiority trials
Current practice around the use of estimands in cluster randomised trials, and the impacts of informative cluster size on inferences
Driving innovation in late phase trials for neuro-degenerative diseases trials:- cross-disease collaboration essential
Involving trialists in evidence synthesis: benefits for trials and meta-analyses
Specifying estimands and estimators in trials with complex designs
Innovative Approaches to Long-Term Follow-Up: Lessons from an Adjuvant Oncology Trial
Getting our ducks in a row: the need for data utility comparisons of healthcare systems data for clinical trials
Data sharing experiences from the publicly accessible WHO TB IPD platform (TB-IPD)
Setting the standard: Implementing change in standardising data collection by using CDISC
Aligning estimators with estimands for data truncation by death in randomised clinical trials: a case study
Exploring methods for borrowing evidence across baskets or subgroups in a clinical trial: a simulation study
Data utility comparison studies (DUCkS) of adjuvant chemotherapy & radiotherapy treatments in the STAMPEDE trial
KTE
Beginning to identify the burdens of safety reporting for trials unit staff: an exploratory qualitative study
CrossWord: Consent to access and use healthcare systems data for clinical trials – a review of current language in participant-facing materials
Approaches to facilitate clinical trial conduct in hospitalised children and neonates in resource-constrained settings
Identifying a comprehensive “long list” of outcomes for developing a core outcome set for severe malaria treatment trials: A systematic review and inclusion of outcomes important to patients and caregivers.
Creating a Trial Monitoring Plan (TMP) template with knowledgeable input using a Delphi survey
Learning from Agile programming methodology: using 'retrospectives' to improve database development in clinical trials
Measuring Success in Clinical Transformation Initiatives: Using the BCG DICE ℗ Score to Reflect on RBQM Implementation
Navigating through the re-design of a multi-arm, multi-stage (MAMS) trial in light of external data; introducing tools to make the most of the available randomised evidence
What estimands can be used when interventions may be given more than once?
Strategies for maintaining double-blinding when including treatments with different modalities in multi-arm multi-stage trials: what works?
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