Providing an evidence base for trial conduct best practice

Clinical trials help doctors and patients make better healthcare decisions. The way a trial is conducted and how the data is collected and checked affects how much confidence we can have in its results, as well as the cost of running the trial. Unfortunately, many of the approaches currently used are not based on high-quality evidence and, in some cases, there is little evidence for best practice. 

We aim to plug gaps in the evidence and find better ways of running trials. We are also looking at ways of making trials more cost-effective. 

Our main areas of work

Practical implementation of new trial designs

New trial designs bring new challenges in running these trials. We share our experience of running trials with new designs in several ways. 

Academic trials as regulatory submissions

Our work improves the efficiency of regulatory submissions for academic trials, making the UK a more attractive place for industry. 

Improving communication of trial results

Our research focuses on the communication of trial results to participants, and to healthcare workers and policymakers.

Using healthcare systems data for clinical trials

We are developing evidence on how useful and accessible healthcare systems data is for clinical trials.

Improving central monitoring and data management

We created a monitoring toolkit with useful evidence and tools for clinical trial monitoring. 

Sharing data from clinical trials

We have worked on setting standards and are now developing a new approach to data-sharing requests to the MRC CTU at UCL. 


We developed the KMunicate format to improve how time-to-event data is presented in Kaplan-Meier graphs.