We have undertaken trials in areas of clinical medicine or public health in which there were potentially important questions that required clinical trials, but lack of the necessary expertise or infrastructure to address them effectively.
A randomised placebo controlled trial of a cholinesterase inhibitor in the management of agitation in dementia that is unresponsive to a psychological intervention
A randomised clinical trial as proof of principle of the analgesic effectiveness of cannabinoids on post-operative pain
CANPOP Dose Finding
An open label study: would a single oral dose of a cannabis plant extract (Cannador) help to provide pain relief after surgery.
An International Multicenter, Adaptive, Randomized Double-Blind, Placebo-Controlled Trial of the Safety, Tolerability and Efficacy of Anti-Coronavirus Hyperimmune Intravenous Immunoglobulin for the Treatment of Adult Hospitalized Patients at Onset of Clinical Progression of COVID-19
Multi-centre, randomised, open-label, blinded endpoint assessed, trial of corticosteroids plus intravenous immunoglobulin (IVIG) and aspirin, versus IVIG and aspirin for prevention of coronary artery aneurysms in Kawasaki disease
Leg Ulcers: Bandage comparison, systematic review and IPD meta-analysis
Four-layer compression bandage compared with short stretch bandage for venous leg ulcers: A systematic review and meta-analysis of randomised controlled trials of individual patient data
Prison-based Naloxone-on-release pilot randomised controlled trial investigating the first 10% of a larger trial to reduce drugs-related deaths soon after release
Can the dose of the polymyxin B antibiotic be optimised to be used in babies, children and adolescents?
Platelet Process Improvement Project - Comparison of platelets stored for 2-5 days versus platelets stored for 6-7 days in preventing and treating haemorrhage in thrombocytopenic patients – a randomised controlled trial
A randomised controlled trial of continuous positive airway pressure treatment in older people with obstructive sleep apnoea/hypopnoea syndrome
Prion disease: Systematic review
Systematic review of therapeutic interventions in human prion disease
Transfusion Alternatives Pre-operatively in Sickle-cell disease (TAPS) randomised controlled trial
A randomised controlled trial to evaluate whether use of intrapleural urokinase aids the drainage of multi-septated malignant pleural effusion compared to placebo
A Randomised Controlled Trial Of Prophylactic Vs No-Prophylactic Platelet transfusions in Patients with Haematological malignancies