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Challenging trials outside our main research themes.

We have undertaken trials in areas of clinical medicine or public health in which there were potentially important questions that required clinical trials, but lack of the necessary expertise or infrastructure to address them effectively.

ANYSNAKES

Advancing Management of Systemic Envenoming by testing multiple Antivenoms

BLISTER

The bullous pemphigoid steroids and tetracyclines study

CALM

A randomised placebo controlled trial of a cholinesterase inhibitor in the management of agitation in dementia that is unresponsive to a psychological intervention

CAMS

Cannabis in multiple sclerosis: a randomised, double blind, placebo controlled trial

CANPOP

A randomised clinical trial as proof of principle of the analgesic effectiveness of cannabinoids on post-operative pain

CANPOP Dose Finding

An open label study: would a single oral dose of a cannabis plant extract (Cannador) help to provide pain relief after surgery.

DOMINO

Donepezil and memantine in moderate to severe Alzheimer’s disease

GIN

Granulocytes in Neutropenia clinical study

HLA-Epitope

Trial of HLA epitope matched platelet transfusion in aplastic anaemia and MDS patients

ITAC

An International Multicenter, Adaptive, Randomized Double-Blind, Placebo-Controlled Trial of the Safety, Tolerability and Efficacy of Anti-Coronavirus Hyperimmune Intravenous Immunoglobulin for the Treatment of Adult Hospitalized Patients at Onset of Clinical Progression of COVID-19

KD-CAAP

Kawasaki Disease Coronary Artery Aneurysm Prevention trial

Leg Ulcers: Bandage comparison, systematic review and IPD meta-analysis

Four-layer compression bandage compared with short stretch bandage for venous leg ulcers: A systematic review and meta-analysis of randomised controlled trials of individual patient data

MOSAIC

Multi-centre Obstructive Sleep Apnoea Interventional Cardiovascular trial

N-ALIVE

Prison-based Naloxone-on-release pilot randomised controlled trial investigating the first 10% of a larger trial to reduce drugs-related deaths soon after release

PATCH I & II

Prophylactic Antibiotics for the Treatment of Cellulitis at Home

PedPolyB01

Can the dose of the polymyxin B antibiotic be optimised to be used in babies, children and adolescents?

PPIP

Platelet Process Improvement Project - Comparison of platelets stored for 2-5 days versus platelets stored for 6-7 days in preventing and treating haemorrhage in thrombocytopenic patients – a randomised controlled trial

PREDICT

A randomised controlled trial of continuous positive airway pressure treatment in older people with obstructive sleep apnoea/hypopnoea syndrome

Prion disease: Systematic review

Systematic review of therapeutic interventions in human prion disease

PRION-1

Partially randomised trial of quinacrine in human prion disease

PRISM

Trial of Prion-filtered vs Standard Red cells in Surgical and Multi-transfused Patients

SWET

Softened Water Eczema Trial

TAPS

Transfusion Alternatives Pre-operatively in Sickle-cell disease (TAPS) randomised controlled trial

TIME1

The first therapeutic intervention in malignant pleural effusion trial

TIME2

The second therapeutic intervention in malignant effusion trial

TIME3

A randomised controlled trial to evaluate whether use of intrapleural urokinase aids the drainage of multi-septated malignant pleural effusion compared to placebo

TOPPS

A Randomised Controlled Trial Of Prophylactic Vs No-Prophylactic Platelet transfusions in Patients with Haematological malignancies

VIDEO

Vitamin D evaluation in osteoarthritis