Sharing our expertise in MAMS platform designs
Sharing our expertise in optimising the design, implementation and analysis of MAMS trials is very important to us, as it ensures that the benefits of these novel designs are applied to a diverse range of disease areas.
To share our experience of the MAMS design, we have developed several resources including software updates, papers, book chapters, and tutorials. We also run MAMS courses periodically, and we provide advice on MAMS design through the ‘MAMS clinic’.
MAMS courses
The next MAMS courses will be advertised on the UCL-ICTM website.
MAMS videos/tutorials
We have several recordings available online:
- Workshop tutorials covering different aspects of MAMS platform trials - introduction, motivation, analysis, etc. They are available in the link below.
Watch workshop tutorials for MAMS trials
- Workshop tutorials on nstage examples
Watch workshop tutorial on nstage examples
- Recordings from the MRC CTU at UCL Symposium ‘Innovative phase III randomised clinical trial designs’ (2023). It covered trial designs that have successfully been used to address multiple research questions including MAMS, MAMS-ROCI, PRACTical designs. You can watch the recordings and download the slides in the link below.
MAMS Clinic
We run the ‘MAMS clinic’, an advisory service on how to optimise the design, implementation, and analysis of your MAMS randomised platform trial.
Visit our MAMS Clinic page for more information.
List of MAMS references
Selected MAMS publications:
Design
- Multi-arm, multi-stage platform, umbrella and basket protocols (2017)
- Treatment selection in multi-arm multi-stage designs: With application to a postpartum haemorrhage trial (2023)
- Adding new experimental arms to randomised clinical trials: Impact on error rates (2020)
- Novel designs for multi-arm clinical trials with survival outcomes with an application in ovarian cancer (2003)
Conduct
- This is a platform alteration: a trial management perspective on the operational aspects of adaptive and platform and umbrella protocols (2019)
- Mind the gap? The platform trial as a working environment (2019)
- Flexible trial design in practice - stopping arms for lack-of-benefit and adding research arms mid-trial in STAMPEDE: a multi-arm multi-stage randomized controlled trial (2012)
Analysis
- Impact of lack-of-benefit stopping rules on treatment effect estimates of two-arm multi-stage (TAMS) trials with time to event outcome (2013)
- How do multi-stage, multi-arm trials compare to the traditional two-arm parallel group design – a reanalysis of 4 trials (2009)
Software
- Facilities for optimizing and designing multi-arm multi-stage (MAMS) randomized controlled trials with binary outcomes (2023)
- A menu-driven facility for sample-size calculation in multi-arm, multi-stage randomized controlled trials with time-to-event outcomes: Update (2015)
Book chapter