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'25 at 25': Transforming treatment for gastroesophageal cancer

 As we celebrate 25 years of the MRC Clinical Trials Unit at UCL, we reflect on our clinical trials and studies which have made the biggest difference to patients. Our OE02 and MAGIC (ST02) trials tran…

'25 at 25': Improving clinical trial monitoring

 Clinical trial monitoring involves overseeing how a trial is run, to check that the study protocol and good clinical practice guidelines are being properly followed, and that the data collected are re…

'25 at 25': Defining treatment for ovarian cancer

 In this article in our series celebrating 25 years of smarter studies, global impact and better health, we look at how the MRC CTU at UCL has helped define treatment for ovarian cancer.  Ovarian cance…

'25 at 25': The Multi-Arm Multi-Stage (MAMS) design

 As we celebrate the 25th anniversary of the MRC Clinical Trials Unit at UCL (MRC CTU at UCL), we take pride in reflecting on our pioneering work on the multi-arm multi-stage (MAMS) trial design, which…

'25 at 25': Improving treatment options for children living with HIV

 Treatment options for children often lag behind those for adults. Data from trials conducted in adults cannot be simply extrapolated to children. Children are not mini-adults, and the way drugs are ab…

'25 at 25': Software to help people implement our methods

 The MRC Clinical Trials Unit at UCL has a proud history of methodology research, which aims to find new solutions to challenges faced in clinical research. Over the past 25 years, we have pioneered no…

'25 at 25': Transforming prostate cancer treatment through the STAMPEDE clinical trial

 Prostate cancer is the second most common cancer in the UK and the most common cancer in men. Every year in the UK, around 52,000 people are diagnosed with prostate cancer. Of those diagnosed between …

'25 at 25': ACORD collaboration for multi-arm multi-stage trials in neurodegenerative diseases

 In 2021, the MRC Clinical Trials Unit at UCL founded the national ACORD collaboration in partnership with UCL Queen Square Institute of Neurology and the University of Edinburgh. This ambitious projec…

'25 at 25': Making HIV treatment accessible to people living in sub-Saharan Africa

 While HIV used to be seen as a death sentence, antiretroviral therapy (ART) means people living with HIV can live healthy lives. But in 2000, only around 7000 people in sub-Saharan Africa were receivi…