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'25 at 25': Conducting the first large international randomised controlled trial on tuberculosis treatment for children

 ... children respond to treatment.   As part of our '25 at 25' series, we look back at the SHINE trial, which sought to address this evidence gap. This landmark study was the first randomised controll…

'25 at 25': Reducing deaths among people starting HIV treatment with advanced disease

 ...irst few weeks of treatment. In this part of our ‘25 at 25’ series, we look back at the REALITY trial, which found a way to prevent deaths among people starting HIV treatment with advanced disease.…

'25 at 25': Framework for Adaptive Meta-analysis (FAME) for timely, reliable and thorough results

 In the latest in our ‘25 at 25’ series, celebrating 25 years of the MRC Clinical Trials Unit at UCL, we explore FAME – a collaborative approach to prospective meta-analysis of aggregate data, which sp…

'25 at 25': Ovarian cancer screening: The UKCTOCS trial

 To celebrate the 25th anniversary of the MRC Clinical Trials Unit and World Cancer Day, we highlight our work throughout the past two decades to help detect ovarian cancer earlier. This article is par…

'25 at 25': Optimising treatments for people with cancer

 The cancer trials that hit the headlines tend to be about improving how long people with cancer live or delaying the disease from getting worse. This is obviously very important, particularly for type…

'25 at 25': Saving lives with early HIV treatment

 During the 25th anniversary year of the MRC Clinical Trials Unit at UCL, we celebrate the fact that millions of people with HIV are now living longer, healthier lives thanks to our research. This arti…

'25 at 25': Transforming treatment for gastroesophageal cancer

 As we celebrate 25 years of the MRC Clinical Trials Unit at UCL, we reflect on our clinical trials and studies which have made the biggest difference to patients. Our OE02 and MAGIC (ST02) trials tran…

'25 at 25': Improving clinical trial monitoring

 Clinical trial monitoring involves overseeing how a trial is run, to check that the study protocol and good clinical practice guidelines are being properly followed, and that the data collected are re…

'25 at 25': Defining treatment for ovarian cancer

 In this article in our series celebrating 25 years of smarter studies, global impact and better health, we look at how the MRC CTU at UCL has helped define treatment for ovarian cancer.  Ovarian cance…

'25 at 25': The Multi-Arm Multi-Stage (MAMS) design

 As we celebrate the 25th anniversary of the MRC Clinical Trials Unit at UCL (MRC CTU at UCL), we take pride in reflecting on our pioneering work on the multi-arm multi-stage (MAMS) trial design, which…