Our methodology research at ICTMC 2024
26 Sep 2024
The 7th International Clinical Trials Methodology Conference will feature a wide variety of workshops, talks and poster presentations from MRC Clinical Trials Unit at UCL researchers. The conference is taking place from Monday 30 September to Thursday 3 October in Edinburgh, UK, and brings together trialists from across the globe to present their latest work in trials methodology.
Details of these presentations are summarised in the tables below. We will be tweeting from @MRCCTU using the hashtag #ICTMC2024.
Oral presentations
| Date | Session time | Session | Title | Presenter |
| Tuesday 1 October |
10:45 – 12:05 | PS.1A: New statistical methods | Mixed model power calculations for trials with a continuous outcome and a proportionate treatment effect | Matthew Burnell |
| 10:45 – 12:05 | PS.1B: Lightning Talks | Current practice around the use of estimands in cluster randomised trials, and the impact of informative cluster size on inferences | Dongquan Bi | |
| 13:20 – 14:40 | PS.2A: Putting Innovative Trial Designs into Practice | Working together to learn lessons on delivering Platform Trials | Sharon Love | |
| 15:10 – 16:30 | PS.3A: Lessons for improvement - professional and methodological | Session chair | Claire Vale | |
| Wednesday 2 October | 08:30 – 09:50 | PS.4C - Innovative design and analysis | When should factorial designs be used for late-phase randomised controlled trials? | Ian White |
| 14:10 – 15:30 | PS.6B: Electronic health records and machine learning | Session chair | Macey Murray | |
| Thursday 3 October |
09:00 – 10:00 | PS.8A: Estimands | Estimation of different intercurrent event strategies: guidance and tools to help analysts implement the right estimators | Brennan Kahan |
| A new estimand for non-inferiority active-control trials enables much smaller sample sizes | David Dunn | |||
| 09:00 – 10:00 | PS.8B: Evidence synthesis and data re-use | Involving trialists for better evidence synthesis: Lessons from a case study in COVID-19 | Claire Vale | |
| 09:00 – 10:00 | PS.8C: Participants, Patients & Public - Co-producing trials and methodology research | Walking The Walk – Partnering With Patients In Designing and Delivering A PPI Implementation Plan | Richard Stephens | |
| 10:20 – 11:05 | PS.9C: Cluster RCTs | Extending platform trial methodology to factorial cluster randomised trials in care homes | Andrew Copas | |
| 10:20 – 11:05 | PS.9D: Data management and monitoring | A framework for protocol deviations (non-compliances) in UK academic trials units | Sharon Love |
Posters
Poster sessions will run Tuesday 1 and Wednesday 2 October during morning, lunch, and afternoon breaks.
| Title | Presenter |
| Getting our ducks in a row: the need for data utility comparisons of healthcare systems data for clinical trials | Macey Murray |
| Data utility comparison studies (DUCkS) of adjuvant chemotherapy & radiotherapy treatments in the STAMPEDE trial | Macey Murray |
| Creating a Trial Monitoring Plan (TMP) template with knowledgeable input using a Delphi survey | Shiva Taheri |
| An exploratory study to identify the burdens of safety reporting | Jemima Thompson |
| CrossWord: Consent to access and use routine healthcare systems data for randomised clinical trials – a review of current language in participant-facing materials | Kate Roberts |
| Use of Participate in OCTOPUS | Alvin Daramola-Rose |
| Exploring different objectives in non-inferiority trials | Conor Tweed |
| Current practice around the use of estimands in cluster randomised trials, and the impacts of informative cluster size on inferences | Dongquan Bi |
| A systematic review and qualitative study to identify a “long list” of outcomes to guide a core outcome set for severe malaria treatment trials development | Gideon Darko Asamoah |
| Sample size calculation for the ROCI design | Henry Bern |
|
Strategies for maintaining double-blinding when including treatments with different modalities in multi-arm multi-stage trials: what works? |
James Carpenter |
| Involving trialists in evidence synthesis: benefits for trials and meta-analyses | Jayne Tierney |
| Specifying estimands and estimators in trials with complex designs | Jingyi Xuan |
| What estimands can be used when interventions may be given more than once? | Joanna Hindley |
| Innovative Approaches to Long-Term Follow-Up: Lessons from an Adjuvant Oncology Trial | Katie Hullock |
| Learning from Agile programming methodology: using 'retrospectives' to improve database development in clinical trials | Lindsey Masters |
| A qualitative focus group study evaluating how to communicate clinical trials with reduced treatment schedules to patients with advanced cancer | Sophie Merrick |
| Data sharing experiences from the publicly accessible WHO TB IPD platform (TB-IPD) | Stella Fabiane, Ruth Goodall on behalf of the WHO IPD Steering Committee |
| Implementing change in standardising data collection by using CDISC | Stephen Townsend |
| Aligning estimators with estimands for data truncation by death in randomised clinical trials: a case study | Tra My Pham |
| Exploring methods for borrowing evidence across baskets or subgroups in a clinical trial: a simulation study | Wenyue LI |
| Approaches to facilitate clinical trial conduct in hospitalised children and neonates in resource-constrained settings | Francesca Schiavone, Elizabeth George |
| Systematically identifying activities to improve the usefulness and impact of trials and meta-analyses | Annabelle South |
| The SHOW RESPECT Adaptable Framework for planning how to share trial results with participants: qualitative findings from interviews with trial participants and site staff | Annabelle South |
| Measuring Success in Clinical Transformation Initiatives: Using the BCG DICE ℗ Score to Reflect on RBQM Implementation | Mags Fraser |
|
Navigating through the re-design of a multi-arm, multi-stage (MAMS) trial in light of external data; introducing tools to make the most of the available randomised evidence |
Elena Frangou |
Educational workshops
| Date | Time | Title | Speakers |
| Monday 30 September | 14:00 – 17:00 | A practical guide to the design, analysis, interpretation and reporting of factorial trials | Brennan Kahan, Alan Montgomery, Edmund Juszczak, Sophie Hall |
| Thursday 3 October | 13:00 – 16:00 | Can Healthcare Systems Data be relied upon for measuring clinical trial outcomes? An updated perspective | Rob Trubey, Matt Sydes, Sharon Love, Macey Murray |
Further information: