New podcast episode: Optimising treatments with the new MAMS-ROCI design

21 Sep 2023

In the latest episode of the Trial Talk podcast, we explore the MAMS-ROCI design, a type of multi-arm multi-stage design that can be used to optimise any continuous aspect of a treatment, such as frequency, duration or dose.  

Matteo Quartagno, a statistician from the MRC CTU at UCL, talks about the motivation for developing this new design and key factors to consider when planning to use it. He presents the REFINE-Lung trial as an example of how researchers can use the MAMS-ROCI design to find out how often we should be giving immunotherapy to treat lung cancer.  

Access the transcript.

The Trial Talk podcast is hosted and produced by Charlotte Hartley and Berta Terre-Torras, our Science Communications Officers. For questions or feedback on the series, message us on Twitter @MRCCTU, LinkedIn, or send us an email.   

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Further information:

• Our work on design methodology
• Link to paper "REFINE-Lung implements the MAMS-ROCI design (Lancet Oncology)"
• Link to paper "The REFINE-Lung case study paper"
• Link to paper "Rethinking non-inferiority: a practical trial design for optimising treatment duration"