Angela Meade, Principal Research Scientist

Angela joined the MRC Clinical Trials Unit in December 1999 as a Clinical Trial Manager for the unit’s first multi-arm trial, FOCUS.  She worked on a number of colorectal cancer clinical trials, before becoming a Project Lead in 2007. Angela has since led a prison-based trial investigating the use of take-home naloxone (n-ALIVE) as well as a number of international oncology trials. Most recently Angela is responsible for leading the SORCE and RAMPART trials and co-leads the Add-Aspirin trial. 

On joining UCL, Angela led on the design and set-up of the MSc Clinical Trials and was Programme Director for the programme from 2016 to 2022. Angela is currently the Taught Education Lead for the UCL Institute of Clinical Trials and Methodology (ICTM) and the co-lead of the EDI team at ICTM.

Angela has a PhD from the University of Ulster and an MSc in Clinical Trials from the London School of Hygiene and Tropical Medicine (LSHTM). Angela is a Senior Fellow of the Higher Education Academy.

Selected publications

Oza, B., Eisen, T., Frangou, E., Stewart, G. D., Bex, A., Ritchie, A. W. S., . . . Meade, A. (2022). External Validation of the 2003 Leibovich Prognostic Score in Patients Randomly Assigned to SORCE, an International Phase III Trial of Adjuvant Sorafenib in Renal Cell Cancer. Journal of Clinical Oncology. doi:10.1200/JCO.21.01090

Meade, A., Oza, B., Frangou, E., Smith, B., Bryant, H., Kaplan, R., . . . Parmar, M. K. B. (2021). RAMPART: A model for a regulatory-ready academic-led phase III trial in the adjuvant renal cell carcinoma setting. Contemporary Clinical Trials, 108, 106481. doi:10.1016/j.cct.2021.106481

Oza B, Frangou E, Smith B, Bryant H . . .  Meade A. (2021). RAMPART: A phase III multi-arm multi-stage trial of adjuvant checkpoint inhibitors in patients with resected primary renal cell carcinoma (RCC) at high or intermediate risk of relapse. Contemporary Clinical Trials, 108,106482, doi:10.1016/j.cct.2021.106482

Eisen, T., Frangou, E., Oza, B., Ritchie, A. W. S., Smith, B., Kaplan, R., . . . Meade, A. (2020). Adjuvant Sorafenib for Renal Cell Carcinoma at Intermediate or High Risk of Relapse: Results From the SORCE Randomized Phase III Intergroup Trial. Journal of Clinical Oncology, 38 (34), 4064-4075. doi:10.1200/jco.20.01800

Meade, A. M., Bird, S. M., Strang, J., Pepple, T., Nichols, L. L., Mascarenhas, M., . . . Parmar, M. K. B. (2017). Methods for delivering the UK's multi-centre prison-based naloxone-on-release pilot randomised trial (N-ALIVE): Europe's largest prison-based randomised controlled trial. Drug and alcohol review. doi:10.1111/dar.12592

Maughan, T. S., Meade, A. M., Adams, R. A., Richman, S. D., Butler, R., Fisher, D., . . . Kaplan, R. (2014). A feasibility study testing four hypotheses with phase II outcomes in advanced colorectal cancer (MRC FOCUS3): a model for randomised controlled trials in the era of personalised medicine?. British Journal of Cancer, 110 (9), 2178-2186. doi:10.1038/bjc.2014.182

Research Interests

• Clinical Trials in Cancer
• Clinical Trials Conduct Methodology

Research Areas

• Cancer
• Methodology
• Education
• Other Areas