A randomised trial of epirubicin and cyclosphamide versus epirubicin and paclitaxel in the treatment of women with metastatic breast cancer

A randomised trial of post-operative portal vein infusion of fluorouracil vs surgery alone for colorectal cancer, and of peri-operative radiotherapy vs no radiotherapy for rectal cancer

Adjuvant chemotherapy in invasive bladder cancer: a systematic review and meta-analysis of individual patient data

Adjuvant Chemotherapy for Muscle-invasive Bladder Cancer: A Systematic Review and Meta-analysis of Individual Participant Data from Randomised Controlled Trials

Neoadjuvant chemotherapy in invasive bladder cancer: update of a systematic review and meta-analysis of individual patient data

Big Lung Trial: A randomised trial to determine the value of cisplatin-based chemotherapy for all patients with non-small cell lung cancer

Two adjuvant chemotherapy regimens in the treatment of osteosarcoma

A randomised pilot study of two drug combinations in patients with osteosarcoma

A randomised trial of two-drug versus multi-drug chemotherapy in the treatment of operable osteosarcoma

A phase II study of cisplatin, ifosfamide and doxorubicin (PIA) chemotherapy in operable primary, axial skeletal and metastatic osteosarcoma

A phase II study of Adriamycin and cisplatin in spindle cell sarcoma of bone other than osteosarcoma

A randomised trial of chemotherapy with or without granulocyte colony stimulating factor (G-CSF) in operable osteosarcoma

Medical Research Council Study of Misonidazole in Conjunction with Radiotherapy for the Treatment of Malignant Gliomas (Astrocytomas) Grades III and IV

A Medical Research Council Study of Two Radiotherapy Dose Regimens for the Treatment of Adult Patients with Malignant Gliomas Grades III and IV

A study of CCNU with and without benznidazole in the treatment of recurrent grades 3 and 4 astrocytomas

Randomised trial on the efficacy of radiotherapy for cerebral low-grade glioma in the adult: EORTC 22845 randomised trial

A randomised trial of adjuvant chemotherapy in high grade malignant glioma

Temozolomide versus PCV chemotherapy in the treatment of recurrent malignant glioma

Primary chemotherapy with temozolomide vs. radiotherapy in patients with low grade glioma after stratification for genetic 1p loss: a phase III study. Intergroup Study (EORTC 22033-26033)

Phase III trial on concurrent and adjuvant temozolomide chemotherapy in non-1p/19q deleted anaplastic glioma. The CATNON Intergroup trial

Autologous stem cell transplantation for malignancy: a systematic review of the literature

Concomitant chemoradiotherapy versus radiotherapy for cervical cancer: a systematic review and meta-analysis of individual patient data.

Concomitant hydroxyurea plus radiotherapy versus radiotherapy for carcinoma of the uterine cervix: a systematic review

Neoadjuvant chemotherapy for locally advanced cervical cancer: a systematic review and meta-analysis of individual patient data

A randomised multicentre trial of continuous hyperfractionated accelerated radiotherapy (CHART) versus conventional radiotherapy

A randomised multicentre trial of continuous hyperfractionated accelerated radiotherapy (CHART) versus conventional radiotherapy in head and neck cancer

A large phase III multi-centre randomised trial to determine the impact of timing of surgery and chemotherapy in newly diagnosed patients with advanced epithelial ovarian, primary peritoneal or fallopian tube cancer

A three arm randomised controlled trial comparing either continuous chemotherapy plus cetuximab, or intermittent chemotherapy with standard continuous palliative combination chemotherapy with oxaliplatin and a fluoropyrimidine in first line treatment of metastatic colorectal cancer

A two-arm phase II randomised trial of intermittent chemotherapy plus continuous cetuximab and of intermittent chemotherapy plus intermittent cetuximab in first line treatment of patients with K-ras-normal (wild-type) metastatic colorectal cancer

Does anti-EGFR therapy improve outcome in advanced colorectal cancer? A systematic review and meta-analysis

Drug treatment for bowel cancer: making the best choices when a milder treatment is needed

Chemotherapy for advanced, recurrent or metastatic endometrial carcinoma

A randomised trial of the European and American Osteosarcoma Study group to optimize treatment strategies for resectable osteosarcoma based on the histological response to pre-operative chemotherapy

A study to determine the feasibility of molecular selection of therapy using KRAS, BRAF and topo-1 in patients with metastatic or locally advanced colorectal cancer

A molecularly-stratified randomised controlled trial programme for patients with advanced colorectal (bowel) cancer

Chemotherapy in adult high-grade glioma: a systematic review and meta-analysis of individual patient data from 12 randomised trials

A double-blind, placebo-controlled, three arm randomised multi-centre GCIG trial of AZD2171 in patients with ovarian cancer

Chemotherapy with or without bevacizumab for ovarian cancer, primary peritoneal cancer or fallopian tube cancer

An international phase III randomised trial of dose fractionated chemotherapy compared to standard three weekly chemotherapy, following immediate primary surgery or as part of delayed primary surgery, for women with newly diagnosed epithelial ovarian, fallopian tube or primary peritoneal cancer

A phase 3 randomised trial investigating the combination of dose-fractionated chemotherapy and bevacizumab compared to either strategy alone for the first-line treatment of women with newly diagnosed high-risk stage III-IV epithelial ovarian, fallopian tube or primary peritoneal cancer

Induction chemotherapy and CHART in non-small cell lung cancer

Three versus six courses of etoposide, cyclophosphamide, methotrexate and voncristine versus six courses of etoposide and ifosfamide in small cell lung cancer

A phase II trial of alternating chemotherapy and radiotherapy in small cell lung cancer

A randomised trial of post-operative radiotherapy in non-small cell lung cancer

A randomised trial of 4-drug vs less intensive 2-drug chemotherapy in the palliative treatment of patients with non-small cell lung cancer and a poor prognosis

A randomised trial of palliative 2-fraction vs more intensive 13-fraction radiotherapy for patients with inoperable NSCLC and a good performance status

Adding GCSF (lenograstim) to chemotherapy to try and increase the dose intensity of chemotherapy given to patients with small cell lung cancer

Adding GCSF (filgrastim) to chemotherapy to try and increase the dose intensity of chemotherapy given to patients with small cell lung cancer

A randomised trial of oral etoposide vs intravenous multi-drug chemotherapy in the palliative treatment of patients with small cell lung cancer and a poor prognosis

A randomised trial of supportive treatment with or without immediate thoracic radiotherapy in the prevention and palliation of symptoms in patients with inoperable non-small cell lung cancer and minimal thoracic symptoms

A randomised controlled clinical trial of endobronchial treatment versus external beam radiotherapy in the management of endotracheal or endobronchial obstruction by lung cancer

A randomised controlled intensification clinical trial of chemotherapy with or without recombinant human granulocyte colony stimulating factor (G-CSF) in small-cell lung cancer

A randomised trial of neo-adjuvant chemotherapy followed by resection versus radiotherapy in patients with T3, N1, M0 or T1-3, N2, M0 non-small cell lung cancer (NSCLC)

A randomised clinical trial of isosfamide, carboplatin and etoposide with mid-cycle vincristine (ICE-V) versus standard practice chemotherapy in patient with small-cell lung cancer (SCLC) and good performance status

Surgical resection with or without pre-operative chemotherapy in patients with operable non-small cell lung cancer

Chemotherapy and supportive care versus supportive care for advanced non-small cell lung cancer: A systematic review and meta-analysis of individual patient data

Adjuvant chemotherapy and surgery (with or without radiotherapy) versus surgery (with or without radiotherapy) for non-small cell lung cancer: Two systematic reviews and meta-analyses of individual patient data

Postoperative radiotherapy for non‐small cell lung cancer

Preoperative chemotherapy for non-small cell lung cancer: a systematic review and meta-analysis of individual participant data

Should tyrosine kinase inhibitors be considered for advanced non-small cell lung cancer with wild type EGFR? Two systematic reviews and meta-analyses of randomised trials

A multicentre evaluation of National Cancer Institute protocol 89-C-41 (with minor modifications) in Burkitt or Burkitt-like non-Hodgkin lymphoma

A randomised trial of therapy for advanced Hodgkin lymphoma

A randomised trial of active symptom control with or without chemotherapy in patients with malignant pleural mesothelioma

Randomised controlled clinical trial of surgery with or without pre-operative chemotherapy in the treatment of respectable cancer of the oesophagus

A randomised controlled trial comparing standard chemotherapy followed by resection versus ECX chemotherapy followed by resection in patients with resectable adenocarcinoma of the oesophagus

Preoperative radiotherapy for oesophageal carcinoma: systematic review and meta-analysis of individual patient data

Early treatment based on CA125 levels alone versus delayed treatment based on conventional clinical indicators

Phase III study of Erlotinib vs. observation in ovarian cancer

A randomised controlled trial of transcutaneous oestrogen patches versus LHRH agonists in prostate cancer

A randomised trial of prophylactic cranial irradiation in patients with limited disease SCLC and a complete response after induction therapy

A randomised trial of oral sodium clodronate versus a matching placebo in patients with locally advanced prostatic adenocarcinoma

A randomised trial of oral sodium clodronate versus a matching placebo in patients with metastatic prostate adenocarcinoma.

Radical prostatectomy vs radical radiotherapy vs no immediate treatment for localised prostate cancer: a randomised controlled trial

A randomised trial of hormone therapy plus radical radiotherapy versus hormone therapy alone in non-metastatic prostate cancer

Prostate MRI Imaging Study - Evaluation of multi-parametric magnetic imaging in the diagnosis and characterisation of prostate cancer

Quality of life after treatment of brain metastases

Radiotherapy and androgen deprivation in combination after local surgery. A randomised controlled trial in prostate cancer

Renal Adjuvant MultiPle Arm Randomised Trial: An international investigator-led phase III multi arm multi stage multi-centre randomised controlled platform trial of adjuvant therapy in patients with resected primary renal cell carcinoma (RCC) at high or intermediate risk of relapse

A randomised controlled trial of Interferon-a, Interleukin-2 and 5-Fluorouracil vs Interferon-a alone in patients with advanced renal cell carcinoma

A randomised controlled trial of high dose versus standard dose conformal radiotherapy for localised prostate cancer

Adjuvant chemotherapy for localised resectable soft-tissue sarcoma of adults: meta-analysis of individual participant data

A multi-centre phase III double-blind placebo-controlled study designed to examine the efficacy and tolerability of sorafenib (Nexavar) in patients with resected (total or partial) primary renal cell carcinoma (RCC) at high or intermediate risk of relapse

A randomised, controlled trial of pre- and post-operative chemotherapy in patients with operable gastric and lower oesophageal cancer

A randomised phase II/III trial of perioperative chemotherapy with or without bevacizumab in operable oesophagogastric adenocarcinoma and a feasibility study evaluating lapatinib in HER-2 positive oesophagogastric adenocarcinomas and (in selected centres) MRI and PET/CT sub-studies

Systemic Therapy in Advancing or Metastatic Prostate cancer: Evaluation of Drug Efficacy

Addition of bisphosphonates to standard of care in men with localised, hormone-sensitive prostate cancer: a systematic review and meta-analyses of aggregate data

Addition of docetaxel to standard of care in men with localised hormone-sensitive prostate cancer: a systematic review and meta-analyses of aggregate data

Addition of abiraterone to standard of care in men with metastatic hormone-sensitive prostate cancer: a systematic review and meta-analyses of aggregate data

What is the optimal systemic treatment of men with metastatic, hormone-sensitive prostate cancer? a systematic review and network meta-analyses of aggregate data

Addition of bisphosphonates to standard of care in men with metastatic, hormone-sensitive prostate cancer: a systematic review and meta-analyses of aggregate data

Addition of docetaxel to standard of care in men with metastatic, hormone-sensitive prostate cancer: a systematic review and meta-analyses of aggregate data

Addition of prostate radiotherapy to ADT in men with metastatic, hormone-sensitive prostate cancer: a systematic review and meta-analyses of aggregate data

A prospective study of surveillance in stage 1 non-seminomatous testicular tumours

Adjuvant bleomycin, etoposide and cisplatin (BEP) in the treatment of "high risk" stage I non-seminomatous germ cell tumours

A randomised trial of two vs five CT scans in the surveillance of patients with stage I non-seminomatous germ cell tumours of the testis

Randomised trial of carboplatin- vs cisplatin based chemotherapy for good prognosis metastatic non-seminomatous germ cell tumours

A prospective study of risk factors for carcinoma in situ of the contralateral testis in patients with testicular cancer

A randomised trial of single agent carboplatin vs etoposide and cisplatin for advanced metastatic seminoma

A randomised trial of BEP (bleomycin, etoposide, cisplatin) vs BOP/VIP-B (bleomycin, vincristine, cisplatin, etoposide, ifosfamide cisplatin, bleomycin) and of the same regimens with or without G-CSF in poor prognosis metastatic germ cell tumours

Prognostic factors for patients with advanced seminoma treated with platinum based chemotherapy

Prognostic factors in patients progressing after platinum-based chemotherapy for metastatic non-seminomatous germ cell tumours

Post chemotherapy residual masses in germ cell tumour patients

Adjuvant bleomycin, vincristine and cisplatin for high-risk stage I non-seminomatous germ cell tumours

A randomised trial of 3 cycles of BEP versus 3 cycles of BEP plus 1 cycle of EP and the 3-day versus the 5-day schedule in good prognosis metastatic germ cell cancer

A randomised trial of BEP vs Taxol-BEP in histologically proven metastatic germ cell cancer with intermediate prognosis

A randomised phase II trial of intensive induction chemotherapy (CBOP/B15EP) and standard BEP chemotherapy in poor prognosis male germ cell tumours

A study to collect blood and tissue samples from consenting patients who have been diagnosed with kidney cancer

Trial of imaging and schedule in seminoma testis

UK Collaborative Trial of Ovarian Cancer Screening

UK Ovarian Cancer Population Study